abstract：BACKGROUND:Traumatic pneumothoraces are a common consequence of major trauma. Despite this, there is a paucity of literature regarding their optimal management, including the role of conservative treatment. The aim of this study was to assess the treatment, complications, and outcomes of traumatic pneumothoraces in pat...

journal_title：Chest

authors： Walker SP,Barratt SL,Thompson J,Maskell NA

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:We designed and conducted this multicenter randomized active-controlled open-label trial to evaluate the efficacy of acupuncture, auricular point pressing, and nicotine replacement therapy (NRT) on tobacco cessation in the Chinese population. METHODS:This randomized controlled trial was conducted in seven h...

journal_title：Chest

authors： Wang YY,Liu Z,Wu Y,Yang L,Guo LT,Zhang HB,Yang JS,Chinese Acupuncture for Tobacco Cessation Research Team.

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Lymphangioleiomyomatosis (LAM) is a destructive lung disease of women caused by proliferation of neoplastic-like LAM cells, with mutations in the TSC1/2 tumor suppressor genes. Based on case reports, levels of cancer antigen 125 (CA-125), an ovarian cancer biomarker, can be elevated in patients with LAM. We ...

journal_title：Chest

authors： Glasgow CG,Pacheco-Rodriguez G,Steagall WK,Haughey ME,Julien-Williams PA,Stylianou MP,Gochuico BR,Moss J

更新日期：2018-02-01 00:00:00

abstract：:In the past decade and a half, the introduction of new therapeutic agents has revolutionized the management of pulmonary arterial hypertension (PAH). These new treatment options have improved the quality of life and survival in PAH. With an armamentarium of options available, the identification of unique phenotypes ca...

journal_title：Chest

authors： Medrek SK,Sahay S

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Failure to reliably diagnose ARDS may be a major driver of negative clinical trials and underrecognition and treatment in clinical practice. We sought to examine the interobserver reliability of the Berlin ARDS definition and examine strategies for improving the reliability of ARDS diagnosis. METHODS:Two hu...

journal_title：Chest

authors： Sjoding MW,Hofer TP,Co I,Courey A,Cooke CR,Iwashyna TJ

更新日期：2018-02-01 00:00:00

abstract：:Pulmonary hypertension (PH) due to chronic lung disease is associated with a poor prognosis, regardless of the underlying respiratory condition. Updated PH guidelines recommend optimal treatment of the underlying lung disease, including long-term oxygen therapy, in patients with chronic hypoxemia despite the lack of r...

journal_title：Chest

authors： Harari S,Elia D,Humbert M

更新日期：2018-01-01 00:00:00

abstract：:COPD and OSA are both highly prevalent, which implies that both disorders occurring together (overlap syndrome) is likely to be common based on chance association alone. However, different clinical COPD phenotypes influence the likelihood of coexisting OSA in that the increased lung volumes and low BMI associated with...

journal_title：Chest

authors： McNicholas WT

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Several cross-sectional and short-term studies suggest that patient-reported outcomes (PROs) may be useful to help predict COPD exacerbations, but evidence from long-term prospective cohort studies is lacking. Our aim was to assess if PROs add to the prediction of exacerbations. METHODS:Four hundred eight p...

journal_title：Chest

authors： Strassmann A,Frei A,Haile SR,Ter Riet G,Puhan MA

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Much controversy persists regarding the place of statin drugs in the treatment of patients with COPD. This systematic review and meta-analysis sought to determine the clinical efficacy of statin therapy in COPD. METHODS:We searched MEDLINE, EMBASE, the Cochrane Database, and PubMed for relevant clinical stu...

journal_title：Chest

authors： Zhang W,Zhang Y,Li CW,Jones P,Wang C,Fan Y

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Urine output (UO) is a vital sign for critically ill patients, but standards for monitoring and reporting vary widely between ICUs. Careful monitoring of UO could lead to earlier recognition of acute kidney injury (AKI) and better fluid management. We sought to determine if the intensity of UO monitoring is ...

journal_title：Chest

authors： Jin K,Murugan R,Sileanu FE,Foldes E,Priyanka P,Clermont G,Kellum JA

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Cough is a common symptom prompting patients to seek medical care. Like patients in the general population, patients with compromised immune systems also seek care for cough. However, it is unclear whether the causes of cough in immunocompromised patients who are deemed unlikely to have a life-threating cond...

journal_title：Chest

authors： Rosen MJ,Ireland B,Narasimhan M,French C,Irwin RS,CHEST Expert Cough Panel.

更新日期：2017-11-01 00:00:00

abstract：:Tobacco smoking during pregnancy is the most important modifiable risk factor for adverse pregnancy outcomes and long-term health complications for mother and baby. Tobacco use during pregnancy has decreased in high-income countries but not in Indigenous women in Australia, New Zealand, the United States, and Canada. ...

journal_title：Chest

authors： Gould GS,Lim LL,Mattes J

更新日期：2017-10-01 00:00:00

abstract：:The call for meaningful patient and family engagement in research has recently gained considerable momentum. This article defines patient and family engagement broadly and specifically in clinical research. Using a multicenter, North American weaning trial as an exemplar, we describe our early experiences as clinical ...

journal_title：Chest

authors： Burns KEA,Devlin JW,Hill NS

更新日期：2017-10-01 00:00:00

abstract：CASE PRESENTATION:A previously healthy 62-year-old woman was transferred to the ICU from the medical ward with acute bronchospastic respiratory failure requiring intubation and mechanical ventilation. Four weeks before, the patient was vacationing in Arizona and acquired a mildly productive cough as well as mild dyspne...

journal_title：Chest

authors： Hountras P,Cajigas H

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:Many critically ill patients who die will do so after a decision has been made to withhold/withdraw life-sustaining therapy. The objective of this study was to document the characteristics of ICU patients with a decision to withhold/withdraw life-sustaining treatment, including the types of supportive treatm...

journal_title：Chest

authors： Lobo SM,De Simoni FHB,Jakob SM,Estella A,Vadi S,Bluethgen A,Martin-Loeches I,Sakr Y,Vincent JL,ICON investigators.

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:The protein deacetylase sirtuin-1 (SIRT1) is an antiaging molecule that is decreased in the lung in patients with COPD. Recently, SIRT1 was reported to be detectable in serum, but serum SIRT1 (s120S) levels have not yet been reported in patients with COPD. METHODS:Serum SIRT1 protein of all samples was meas...

journal_title：Chest

authors： Yanagisawa S,Papaioannou AI,Papaporfyriou A,Baker JR,Vuppusetty C,Loukides S,Barnes PJ,Ito K

更新日期：2017-08-01 00:00:00

abstract：CASE PRESENTATION:An 84-year-old man without a history of smoking presented with progressive dyspnea of 6 months' duration accompanied by fatigue and unintentional weight loss. He denied fever, chills, chest pain, hemoptysis, rash, joint pains, or muscle aches. He had multiple hospitalizations for similar presentations...

journal_title：Chest

authors： Fakih HAM,Samra Y,Ataya A,Prasad A,Papierniak E,Wakefield D,Urbine D

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Some patients with autoimmune characteristics and idiopathic interstitial pneumonia, particularly usual interstitial pneumonia (UIP), do not fit neatly into the category of connective tissue disease-associated interstitial lung disease (CTD-ILD), idiopathic pulmonary fibrosis (IPF), or recently proposed yet ...

journal_title：Chest

authors： Collins BF,Spiekerman CF,Shaw MA,Ho LA,Hayes J,Spada CA,Stamato CM,Raghu G

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:COPD is associated with reduced physical capacity. However, it is unclear whether pulmonary emphysema, which can occur without COPD, is associated with reduced physical activity in daily life, particularly among people without COPD and never smokers. We hypothesized that greater percentage of emphysema-like ...

journal_title：Chest

authors： Lo Cascio CM,Quante M,Hoffman EA,Bertoni AG,Aaron CP,Schwartz JE,Avdalovic MV,Fan VS,Lovasi GS,Kawut SM,Austin JHM,Redline S,Barr RG

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Whether the localization of nonmassive pulmonary embolism (PE) is associated with the short-term and long-term prognosis of patients remains unknown. Our aim was to characterize associations of nonmassive PE localization with risks of recurrent VTE, major bleeding, and mortality during and after anticoagulat...

journal_title：Chest

authors： Gouin B,Blondon M,Jiménez D,Fernández-Capitán C,Bounameaux H,Soler S,Duce R,Sahuquillo JC,Ruiz-Giménez N,Monreal M,RIETE investigators.

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Exhaled breath temperature (EBT) is a new noninvasive method for the study of inflammatory respiratory diseases with a potential to reach clinical practice. However, few studies are available regarding the validation of this method, and they were mainly derived from small, pediatric populations; thus, the ra...

journal_title：Chest

authors： Carpagnano GE,Foschino-Barbaro MP,Crocetta C,Lacedonia D,Saliani V,Zoppo LD,Barnes PJ

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Direct (pulmonary) and indirect (extrapulmonary) ARDS are distinct syndromes with important pathophysiologic differences. The goal of this study was to determine whether clinical characteristics and predictors of mortality differ between direct or indirect ARDS. METHODS:This retrospective observational coho...

journal_title：Chest

authors： Luo L,Shaver CM,Zhao Z,Koyama T,Calfee CS,Bastarache JA,Ware LB

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Balloon pulmonary angioplasty (BPA) in chronic thromboembolic pulmonary hypertension (CTEPH) improves hemodynamics and exercise capacity. However, its effect on respiratory function is unclear. Our objective was to investigate the effect of BPA on respiratory function. METHODS:We enrolled patients with inop...

journal_title：Chest

authors： Akizuki M,Serizawa N,Ueno A,Adachi T,Hagiwara N

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Surgical patients with OSA are at increased risk for perioperative complications. Postoperative supplemental oxygen is commonly used, but it may contribute to respiratory depression in patients with OSA receiving opioids. The objective of the study is to investigate the effect of postoperative supplemental o...

journal_title：Chest

authors： Liao P,Wong J,Singh M,Wong DT,Islam S,Andrawes M,Shapiro CM,White DP,Chung F

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The synthetic peptide solnatide is a novel pharmacologic agent that reduces extravascular lung water, blunts reactive oxygen species production, and improves lung function due to its ability to directly activate the epithelial sodium channel. The goal of this study was to investigate the effect of solnatide ...

journal_title：Chest

authors： Zhou Q,Wang D,Liu Y,Yang X,Lucas R,Fischer B

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) combinations are a treatment option for patients with COPD who continue to have symptoms despite treatment with a LAMA or a LABA alone. The Efficacy and Safety of PT003, PT005, and PT001 in Subjects with Moderate-to-Very Severe COPD (PINN...

journal_title：Chest

authors： Martinez FJ,Rabe KF,Ferguson GT,Fabbri LM,Rennard S,Feldman GJ,Sethi S,Spangenthal S,Gottschlich GM,Rodriguez-Roisin R,Arora S,Siler TM,Siddiqui S,Darken P,Fischer T,Maes A,Golden M,Orevillo C,Reisner C

更新日期：2017-02-01 00:00:00

abstract：:Aspiration of a foreign body into the lower airways is a common occurrence and can cause significant morbidity and mortality in humans. Most foreign bodies of the tracheobronchial tree are inanimate. However, the medical literature includes reports of live foreign bodies in the airways. Fish, leeches, and roundworms a...

journal_title：Chest

authors： Ali SR,Mehta AC

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:ICU telemedicine improves access to high-quality critical care, has substantial costs, and can change financial outcomes. Detailed information about financial outcomes and their trends over time following ICU telemedicine implementation and after the addition of logistic center function has not been publishe...

journal_title：Chest

authors： Lilly CM,Motzkus C,Rincon T,Cody SE,Landry K,Irwin RS,UMass Memorial Critical Care Operations Group.

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Long-acting bronchodilators, including long-acting beta2-agonists (LABA) and the anticholinergic tiotropium, are recommended as initial maintenance therapy in COPD. Studies to date have been limited in size and reported ambivalent results on the comparative risk of cardiovascular, cerebrovascular, and pulmon...

journal_title：Chest

authors： Suissa S,Dell'Aniello S,Ernst P

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:There is a growing use of procalcitonin (PCT) to facilitate the diagnosis and management of severe sepsis. We investigated the impact of one to two PCT determinations on ICU day 1 on health-care utilization and cost in a large research database. METHODS:A retrospective, propensity score-matched multivariabl...

journal_title：Chest

authors： Balk RA,Kadri SS,Cao Z,Robinson SB,Lipkin C,Bozzette SA

更新日期：2017-01-01 00:00:00

abstract：:Hyperbaric oxygen therapy, the administration of 100% oxygen at pressures > 1 atm, is believed to promote wound healing by increasing angiogenesis and collagen synthesis. To our knowledge, this treatment modality has never been described in patients with tracheal radionecrosis. Here, we report the case of a 55-year-ol...

journal_title：Chest

authors： Ariza-Prota M,Morales A,Grajeda J,López-Lisbona R,Cubero N,Dorca J,Rosell A

更新日期：2016-12-01 00:00:00

abstract：:Endobronchial ultrasonography (EBUS) has become an invaluable tool in the diagnosis of patients with a variety of thoracic abnormalities. The majority of EBUS procedures are used to diagnose and stage mediastinal and hilar abnormalities, as well as peripheral pulmonary targets, with a probe-based technology. Nearly 1,...

journal_title：Chest

authors： Gildea TR,Nicolacakis K

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:In chronic obstructive pulmonary disease, both smaller and larger airways are affected. FEV1 mainly reflects large airways obstruction, while the later fraction of forced exhalation reflects reduction in terminal expiratory flow. In this study, the objective was to evaluate the relationship between spirometr...

journal_title：Chest

authors： Dilektasli AG,Porszasz J,Casaburi R,Stringer WW,Bhatt SP,Pak Y,Rossiter HB,Washko G,Castaldi PJ,Estepar RSJ,Hansen JE,COPDGene investigators.

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Current functional assessments do not allow a reliable assessment of small airways, which are a major site of disease in COPD. Single-breath washout (SBW) tests are feasible and reproducible methods for evaluating small airway disease. Their relevance in COPD remains unknown. METHODS:We performed a cross-se...

journal_title：Chest

authors： Boeck L,Gensmer A,Nyilas S,Stieltjes B,Re TJ,Tamm M,Latzin P,Stolz D

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy (HCM) is a common genetic disease that may cause left ventricular outflow tract (LVOT) obstruction, heart failure, and sudden death. Recent studies have shown a high prevalence of OSA among patients with HCM. Because the hemodynamics in patients with LVOT obstruction are unstable ...

journal_title：Chest

authors： Nerbass FB,Salemi VMC,Pedrosa RP,Portilho NP,Ferreira-Filho JCA,Moriya HT,Antunes MO,Arteaga-Fernández E,Drager LF,Lorenzi-Filho G

更新日期：2016-11-01 00:00:00

abstract：:Extrapulmonary tuberculosis refers to Mycobacterium tuberculosis involving organs other than the lungs (eg, pleura, lymph nodes, genitourinary tract, abdomen, skin, joints and bones, or meninges). In non-HIV-endemic areas, where reactivation is the predominant mechanism of tuberculosis, pleural involvement occurs in 4...

journal_title：Chest

authors： Gleason JB,Tashtoush B,Mehta J,Savage E,Martinez F,Mehta AC

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited response to currently available therapies. Alveolar type II (ATII) cells act as progenitor cells in the adult lung, contributing to alveolar repair during pulmonary injury. However, in IPF, ATII cells die and are replace...

journal_title：Chest

authors： Serrano-Mollar A,Gay-Jordi G,Guillamat-Prats R,Closa D,Hernandez-Gonzalez F,Marin P,Burgos F,Martorell J,Sánchez M,Arguis P,Soy D,Bayas JM,Ramirez J,Tetley TD,Molins L,de la Bellacasa JP,Rodríguez-Villar C,Rovira I,Fi

更新日期：2016-09-01 00:00:00

abstract：:Disputes regarding life-prolonging treatments are stressful for all parties involved. These disagreements are appropriately almost always resolved with intensive communication and negotiation. Those rare cases that are not require a resolution process that ensures fairness and due process. We describe three recent cas...

journal_title：Chest

authors： Bosslet GT,Baker M,Pope TM

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Increased expression of the human epididymis protein 4 (HE4) was previously described in lung biopsy samples from patients with cystic fibrosis (CF). It remains unknown, however, whether serum HE4 concentrations are elevated in CF. METHODS:Seventy-seven children with CF from six Hungarian CF centers and 57 ...

journal_title：Chest

authors： Nagy B Jr,Nagy B,Fila L,Clarke LA,Gönczy F,Bede O,Nagy D,Újhelyi R,Szabó Á,Anghelyi A,Major M,Bene Z,Fejes Z,Antal-Szalmás P,Bhattoa HP,Balla G,Kappelmayer J,Amaral MD,Macek M Jr,Balogh I

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Obesity is known to be an important risk factor for OSA; however, OSA can also be seen in nonobese patients with a small maxilla and/or mandible as well as in all obese patients with such features. Thus, we hypothesized that regional factors, oropharyngeal crowding associated with fat deposition, and maxillo...

journal_title：Chest

authors： Ito E,Tsuiki S,Maeda K,Okajima I,Inoue Y

更新日期：2016-08-01 00:00:00